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Viral long non-coding RNA regulates virus life-cycle and pathogenicity
Zeyu Li1, Jiaqin Gao1, Xinyu Xiang1
1Department of Biochemistry and Molecular Biology, Jiangsu University School of Medicine, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, China.
Molecular Biology Reports
|March 18, 2022
Summary
Viral infections pose a global threat. This review explores viral long non-coding RNAs (lncRNAs) and their roles in viral life cycles and pathogenicity, highlighting their potential as therapeutic targets.
Area of Science:
- Molecular Biology
- Virology
- Genetics
Background:
- Viral infections remain a significant global health concern, causing substantial mortality.
- Understanding viral replication and infection mechanisms is crucial for developing control strategies.
- Host long non-coding RNAs (lncRNAs) are known regulators of viral infections and antiviral responses.
Purpose of the Study:
- To review the regulatory roles of viral lncRNAs in the viral life cycle and pathogenicity.
- To explore viral lncRNAs as potential therapeutic targets for viral diseases.
- To encourage further research into novel viral lncRNAs and their mechanisms.
Main Methods:
- Literature review focusing on viral lncRNAs.
- Analysis of existing research on lncRNA involvement in viral infection.
- Synthesis of information on viral lncRNA functions and therapeutic potential.
Main Results:
- Viral lncRNAs are involved in multiple stages of the viral life cycle, including replication, gene expression, packaging, assembly, and release.
- Viral lncRNAs can enhance pathogenicity by suppressing host antiviral immunity and maintaining viral latency.
- A limited understanding exists regarding viral lncRNAs compared to host lncRNAs.
Conclusions:
- Viral lncRNAs play critical roles in viral pathogenesis and life cycles.
- Targeting viral lncRNAs presents a promising avenue for developing novel antiviral therapies.
- Further investigation into viral lncRNAs is essential for advancing antiviral strategies.
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