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Updated: Sep 29, 2025
Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
Published on: November 20, 2009
Acellular nerve grafts with bone marrow mesenchymal stem cells/Schwann cells for sciatic nerve regeneration in rats:
Jie Liang1, Liang Luo1, Feifan Xiang1
1Department of Bone and Joint Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Introduction:
The aim of this meta-analysis was to evaluate the effects of acellular nerve grafts (ANGs) with bone marrow mesenchymal stem cells (BMSCs) or Schwann cells (SCs) on the treatment of sciatic nerve defect in rats.
Evidence Acquisition:
Electronic databases were accessed to identify eligible targets. ANGs data were extracted for meta-analysis using Review Manager 5.3.
Evidence Synthesis:
The rats subjected to ANGs+BMSCs or ANGs+SCs are characterized by different sciatic nerve function index, nerve conduction, latency, amplitude, myelin sheath thickness, myelinated nerve fibers and gastrocnemius wet weight. accompanied with evidently superior recovery of limb function. These differences are of statistical significance (P<0.05) when compared to that of control group with ANGs only.
Conclusions:
ANGs with BMSCs or SCs can promote nerve regeneration and functional recovery in peripheral nerve defects.
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