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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
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Chronic Salmonella Infection Induced Intestinal Fibrosis
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NF-kB pathway is involved in microscopic colitis pathogenesis.

Laura Francesca Pisani1, Gianeugenio Tontini2,3, Maurizio Vecchi2,3

  • 1Gastroenterology and Endoscopy Unit, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

The Journal of International Medical Research
|March 18, 2022
PubMed
Summary
This summary is machine-generated.

Microscopic colitis (MC) development involves impaired non-canonical nuclear transcription factor kappa B (NF-kB) inflammatory pathways. This study identified increased expression of specific NF-kB pathway genes in MC patients compared to healthy controls.

Keywords:
Microscopic colitiscollagenous colitisinflammationinflammatory pathwaylymphocytic colitis

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Area of Science:

  • Gastroenterology
  • Immunology
  • Molecular Biology

Background:

  • Microscopic colitis (MC) is an inflammatory bowel disease.
  • The precise inflammatory pathways driving MC pathogenesis remain incompletely understood.

Purpose of the Study:

  • To investigate the inflammatory pathways implicated in the development of microscopic colitis (MC).

Main Methods:

  • Prospective analysis of human intestinal tissues from healthy controls (HC), MC patients, and ulcerative colitis (UC) patients.
  • Utilized RT2 Profiler PCR Array to assess 84 inflammatory and autoimmunity genes.
  • Validated findings using real-time polymerase chain reaction (PCR) on independent MC samples.

Main Results:

  • Gene expression analysis revealed significantly increased levels of C-C motif chemokine ligand 19, C-C motif chemokine ligand 21, lymphotoxin beta, and complement C3 in MC patients compared to HC.
  • These upregulated genes are integral components of the non-canonical nuclear transcription factor kappa B (NF-kB) pathway.
  • Real-time PCR confirmed these elevated gene expression patterns in MC.

Conclusions:

  • The study findings indicate a potential impairment in the non-canonical NF-kB pathway contributes to the development of microscopic colitis.
  • This suggests the non-canonical NF-kB pathway as a potential therapeutic target for MC.