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Spherical nucleic acid reporter-based cascade CRISPR/Cas12a amplifier for stable and sensitive biosensing of
Min Zhou1, Yao Yin1, Yuyan Shi1
1College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, China. chenmei@hnu.edu.cn.
Chemical Communications (Cambridge, England)
|March 18, 2022
Abstract:
Stable and sensitive ctDNA biosensing in complex biological fluid is highly important but still remains a challenge. Herein, we develop a spherical nucleic acid reporter-based cascade CRISPR/Cas12a amplifier with improved stability and sensitivity (5 orders of magnitude).
