THE DEVELOPMENT OF BRONCHOPLEURAL FISTULA
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Updated: Sep 29, 2025

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Rita Costa1, João Maciel2, Pedro Fernandes1
1Department of Cardiothoracic Surgery,Centro Hospitalar Universitário São João, Porto, Portugal.
Abstract:
A 66-year-old male with an aspergiloma in the upper left lobe was submitted to a wedge resection in December 2019. Pneumostasis was performed using biological glue and afterward the test of submersion in water showed no significant alveolopleural leak. In the immediate postoperative period, the patient presented an expanded lung parenchyma and moderate alveolopleural leakage that gradually decreased. A month later the patient was readmitted in intensive care unit with an acute respiratory distress after a sudden episode of coughing with abundant and purulent sputum and significant increase in alveolopleural leakage. Intraoperatively it was found that the pulmonary parenchyma covering the segmental bronchi was necrotic.
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