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Updated: Jul 9, 2026

Efficient SARS-CoV-2 Quantitative Reverse Transcriptase PCR Saliva Diagnostic Strategy utilizing Open-Source Pipetting Robots

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Published on: February 11, 2022

Is large-scale rapid CoV-2 testing a substitute for lockdowns?

Marc Diederichs¹, René Glawion², Peter G Kremsner^3,4

¹Johannes Gutenberg University Mainz, Mainz, Germany.

|March 18, 2022

Summary

Rapid testing did not substitute for contact restrictions during Covid-19. Relaxing restrictions while implementing testing led to more infections, as testing volume was insufficient to offset increased contacts.

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Area of Science:

Epidemiology
Public Health Policy
Infectious Disease Modeling

Background:

Contact restrictions were a primary tool during the Covid-19 pandemic.
Rapid testing emerged as a potential alternative policy instrument in early 2021.
The study investigates if rapid testing can replace contact restrictions.

Purpose of the Study:

To evaluate the impact of a unique policy experiment in Tübingen, Germany.
To assess whether rapid testing could compensate for relaxed contact restrictions.
To determine the net effect of the combined policy on infection rates.

Main Methods:

Utilized the synthetic control method to compare Tübingen county with a control unit.
Analyzed case rates before and during the intervention period (March-April 2021).
Employed an extended SEIR epidemiological model for nuanced interpretation.

Main Results:

The policy experiment resulted in a robust increase in reported Covid-19 cases.
Increased testing initially led to a higher detection rate of existing cases.
Epidemiological modeling, accounting for testing and holiday effects, indicated more infections overall.

Conclusions:

The volume of rapid tests in the Tübingen experiment was insufficient.
Rapid testing did not compensate for the increased transmission from relaxed contact restrictions.
The policy intervention led to a net increase in infections.