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Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Identification of G-quadruplex DNA sequences in SARS-CoV2.

Amit K Maiti1

  • 1Mydnavar, Department of Genetics and Genomics, 2645 Somerset Boulevard, Troy, MI, 48084, USA. akmit123@yahoo.com.

Immunogenetics
|March 18, 2022
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Summary

Researchers found 37 G-quadruplex forming G-rich sequences (QGRSs) in the SARS-CoV-2 genome, primarily upstream of genes. These sequences may offer therapeutic targets for inhibiting viral replication and transcription.

Keywords:
G-quadruplexLTR sequencesSARS-CoV2TherapeuticsUpstream

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Area of Science:

  • Genomics
  • Virology
  • Bioinformatics

Background:

  • G-quadruplex structures and Putative Quadruplex Sequences (PQSs) are prevalent in various genomes, including viral RNA.
  • These sequences are implicated in critical viral functions such as genome replication, gene regulation, and virulence.

Purpose of the Study:

  • To investigate the presence and distribution of potential G-quadruplex structures within the SARS-CoV-2 genome.
  • To explore the potential of targeting these structures for therapeutic intervention against SARS-CoV-2.

Main Methods:

  • Bioinformatic analysis was employed to identify G-quadruplex forming G-Rich Sequences (QGRSs)/PQSs in the SARS-CoV-2 genome.
  • Sequence analysis focused on identifying potential G-quadruplex forming regions and their locations relative to viral genes.

Main Results:

  • Thirty-seven QGRSs/PQSs were identified in the SARS-CoV-2 genome (25 on the forward strand, 12 on the reverse strand).
  • These identified sequences are predominantly located upstream of SARS-CoV-2 genes.

Conclusions:

  • The SARS-CoV-2 genome harbors numerous potential G-quadruplex structures.
  • Existing PQS/QGRS ligands could potentially inhibit SARS-CoV-2 replication and transcription, warranting further experimental validation and exploration as therapeutic agents.