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Structural integrity of corpus callosum in patients with migraine: a diffusion tensor imaging study
Aygul Tantik Pak1, Sebahat Nacar Dogan2, Yildizhan Sengul3
1Department of Neurology, University of Ministry Health, Gaziosmanpasa Training and Research Hospital, Istanbul, Turkey. aa.aygultantik@hotmail.com.
Acta Neurologica Belgica
|March 18, 2022
Summary
Migraine patients show microstructural changes in the brain's corpus callosum (CC), the largest white matter tract. Diffusion tensor imaging revealed differences in CC genu fractional anisotropy (FA) between migraineurs and healthy controls.
Area of Science:
- Neuroimaging
- Neuroscience
- Radiology
Background:
- The corpus callosum (CC) is the largest white matter structure in the brain, crucial for interhemispheric communication.
- Migraine is a complex neurological disorder, and its effects on brain structure are not fully understood.
- Investigating CC microstructural integrity may reveal underlying pathophysiology in migraine.
Purpose of the Study:
- To compare structural differences in the corpus callosum (CC) between individuals with migraine and healthy controls (HC).
- To utilize diffusion tensor imaging (DTI) to assess white matter microstructure in the CC.
- To explore potential correlations between clinical characteristics of migraine and CC structural changes.
Main Methods:
- Diffusion Tensor Imaging (DTI) was employed to acquire microstructural information.
- Fractional Anisotropy (FA) and Apparent Diffusion Coefficient (ADC) values were measured in the genu, splenium, and body of the CC.
- Fifty-one migraine patients and 44 age- and sex-matched healthy controls participated.
Main Results:
- A statistically significant difference in FA values was observed in the genu of the CC between migraine patients and HC (p < 0.001).
- No significant correlation was found between clinical data of migraine patients and FA values in the CC genu via linear regression analysis (p > 0.05).
Conclusions:
- Microstructural alterations in the corpus callosum are suggested in individuals with migraine.
- The specific clinical factors contributing to these observed structural changes in the CC could not be identified in this study.
