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A Clinical Diagnostic Study: Fibulin-2 is a Novel Promising Biomarker for Predicting Infection.
Shidan Li1, Hao Jiang2, Wei Xing3
1Department of Orthopaedics, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, 400042, People's Republic of China.
Infectious Diseases and Therapy
|March 18, 2022
Summary
Fibulin-2 shows promise as a novel biomarker for early infection detection. This new marker performed comparably to established tests like CRP and PCT, and better in specific patient groups.
Area of Science:
- Biomarker discovery
- Infectious disease diagnostics
- Clinical chemistry
Background:
- Infection is a leading cause of hospital morbidity and mortality.
- Early detection and diagnosis of infection are crucial for timely clinical intervention.
- Current diagnostic markers like CRP, PCT, and WBC have limitations in sensitivity and specificity, especially with confounding factors like fever and trauma.
Purpose of the Study:
- To investigate the potential of fibulin-2 as a diagnostic indicator for early infection.
- To evaluate the diagnostic performance of fibulin-2 compared to existing biomarkers.
Main Methods:
- Plasma fibulin-2 concentrations were measured using enzyme-linked immunosorbent assay (ELISA) in emergency department patients.
- Receiver operating characteristic (ROC) curve analysis was employed to assess the diagnostic accuracy of fibulin-2.
Main Results:
- Plasma fibulin-2 levels were significantly elevated in patients with infection.
- Fibulin-2 demonstrated good diagnostic ability (AUC 0.712), outperforming WBC, NEU%, IL-6, and D-dimer, and performing comparably to CRP and PCT.
- Fibulin-2 showed superior performance in diagnosing infection in patients with trauma and performed well in patients with fever.
Conclusions:
- Fibulin-2 is identified as a novel and promising biomarker for predicting infection.
- Fibulin-2 offers a potential improvement in early infection diagnostics, particularly in complex cases involving trauma.
