The Regulatory effect of chlorogenic acid on gut-brain function and its mechanism: A systematic review

Chlorogenic acid (CGA) is a phenolic compound that is widely distributed in honeysuckle, Eucommia, fruits and vegetables. It has various biological functions, including cardiovascular, nerve, kidney, and liver protection, and it exerts a protective effect on human health, according to clinical research and basic research. The intestine and brain are two important organs that are closely related in the human body. The intestine is even called the "second brain" in humans. However, among the many reports in the literature, an article systematically reporting the regulatory effects and specific mechanisms of CGA on the intestines and brain has not been published. In this context, this review uses the regulatory role and mechanism of CGA in the intestine and brain as the starting point and comprehensively reviews CGA metabolism in the body and the regulatory role and mechanism of CGA in the intestine and brain described in recent years. Additionally, the review speculates on the potential biological actions of CGA in the gut-brain axis. This study provides a scientific theory for CGA research in the brain and intestines and promotes the transformation of basic research and the application of CGA in food nutrition and health care.