Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

10.2K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
10.2K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

709
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
709
Aging01:26

Aging

219
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
219
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

276
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
276

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protocol for semi-automatic quantitative bioimaging analysis of synapse loss.

STAR protocols·2026
Same author

NRF2 deficiency is associated with synaptic alterations and ether-linked phospholipid imbalance in the hippocampus.

Redox biology·2025
Same author

Alzheimer's genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses.

Cell reports·2025
Same author

The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-Actin.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024
Same author

Correction: Apolipoprotein E intersects with amyloid-β within neurons.

Life science alliance·2024
Same author

Apolipoprotein E intersects with amyloid-β within neurons.

Life science alliance·2023

Related Experiment Video

Updated: Sep 29, 2025

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP
07:55

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP

Published on: October 17, 2015

12.0K

Aging impact on amyloid precursor protein neuronal trafficking.

Tatiana Burrinha1, Cláudia Guimas Almeida1

  • 1Chronic Diseases Research Center (CEDOC), NOVA Medical School (NMS), Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal.

Current Opinion in Neurobiology
|March 18, 2022
PubMed
Summary

Neuronal aging impacts membrane trafficking, potentially increasing Alzheimer

Area of Science:

  • Neuroscience
  • Cell Biology
  • Aging Research

Background:

  • Neuronal aging is linked to increased Alzheimer's disease risk.
  • Intraneuronal beta-amyloid (Aβ) accumulates in aged brains, independent of genetic mutations.
  • The role of neuronal aging in potentiating Aβ accumulation requires investigation.

Purpose of the Study:

  • To review how neuronal membrane trafficking maintains synapse function during aging.
  • To explore the link between aging, amyloid precursor protein (APP) trafficking, and Aβ production.
  • To identify molecular regulators of APP trafficking in aging neurons.

Main Methods:

  • Literature review focusing on neuronal membrane trafficking.
  • Analysis of APP processing and Aβ production in the context of aging.

More Related Videos

Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons
06:23

Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons

Published on: October 30, 2018

8.1K
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

10.8K

Related Experiment Videos

Last Updated: Sep 29, 2025

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP
07:55

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP

Published on: October 17, 2015

12.0K
Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons
06:23

Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons

Published on: October 30, 2018

8.1K
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

10.8K
  • Examination of evidence linking aging to changes in membrane trafficking and APP metabolism.

    • Main Results:

    • Neuronal aging affects membrane trafficking dynamics.
    • Changes in membrane trafficking during aging influence APP processing.
    • Aging-related alterations in trafficking contribute to increased Aβ production.

    Conclusions:

    • Neuronal membrane trafficking is crucial for synapse function during aging.
    • Disruptions in APP trafficking during neuronal aging may drive Aβ accumulation.
    • Understanding these molecular mechanisms is key to developing strategies against synaptic decline and Alzheimer's disease.