A biocompatible bismuth based metal-organic framework as efficient light-sensitive drug carrier

Area of Science:

• Materials Science
• Nanotechnology
• Drug Delivery

Background:

• Bismuth-based metal-organic frameworks (MOFs) possess low toxicity and photoactivity.
• These properties make them suitable for light-sensitive drug delivery applications.
• Developing efficient drug carriers is crucial for targeted and controlled therapeutic interventions.

Purpose of the Study:

• To investigate the potential of a bismuth-based MOF, SU-101, as a light-sensitive drug carrier.
• To evaluate the loading capacity and light-induced release of ciprofloxacin (CIP) from SU-101.
• To explore the mechanism of drug release and the universality of SU-101 for other drugs.

Main Methods:

• Synthesis and characterization of SU-101 (bismuth and ellagic acid MOF).
• Loading of ciprofloxacin (CIP) into SU-101 and determination of loading ratio.
• Investigation of CIP release kinetics under light illumination.
• Analysis of the interaction mechanism between SU-101 and drug molecules using hydrogen bonding principles.

Main Results:

• SU-101 demonstrated a high ciprofloxacin loading ratio of 85.8%.
• Controlled release of CIP was achieved under light illumination, with a maximum release ratio of 95.56%.
• Hydrogen bonding between ellagic acid and ciprofloxacin was identified as the key mechanism for drug loading and light-triggered release.

Conclusions:

• SU-101 exhibits significant potential as an efficient light-sensitive drug carrier.
• The drug release mechanism is dependent on light-induced disruption of hydrogen bonds.
• SU-101 shows versatility for carrying other drugs (e.g., norfloxacin, amoxicillin, tetracycline, doxorubicin hydrochloride) that can form hydrogen bonds.