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Updated: Sep 29, 2025
Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
Published on: February 1, 2022
Fast screening method for early diagnostic of gastric cancer based on utilization of a chitosan - S-doped graphene -
Damaris-Cristina Gheorghe1, Ruxandra-Maria Ilie-Mihai2, Raluca-Ioana Stefan-van Staden1
1Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021 Bucharest-6, Romania; Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, Bucharest, Romania.
Abstract:
Needle stochastic sensors were developed for the assay of carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA) in different biological samples (e.g., whole blood, tissues, urine, and saliva). Sulfur doped graphene powders were modified with chitosan; paraffin oil was added to form a homogeneous paste that was used as active side of the stochastic sensors. High sensitivities and low limits of determination were achieved for the assay of CA19-9 and CEA in biological samples. The validation of the proposed screening method (which is utilizing the stochastic sensors as screening tools) was made by using real biological samples obtained from confirmed patients with gastric cancer; very good correlations for the concentrations of CEA and CA19-9 were obtained using the needle stochastic sensors.
