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Autosomal aneuploidy in mice: generation and developmental consequences.

J D Gearhart, M T Davisson, M L Oster-Granite

    Brain Research Bulletin
    |June 1, 1986
    PubMed
    Summary

    This review details mouse models for generating aneuploidy, focusing on autosomal trisomy. It summarizes methods for creating trisomic, partially trisomic, and monosomic conceptuses and their developmental effects.

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    Area of Science:

    • * Developmental Biology
    • * Genetics
    • * Mammalian Reproduction

    Background:

    • * Spontaneous aneuploidy in mice is rare.
    • * Aneuploidy, an abnormal chromosome number, can arise from errors in cell division.
    • * Autosomal trisomy, having an extra chromosome copy, is a common aneuploid condition in mice.

    Purpose of the Study:

    • * To review methods for inducing aneuploidy in mouse models.
    • * To describe the production of trisomic, partially trisomic, and monosomic conceptuses.
    • * To summarize the developmental consequences of mouse autosomal trisomies.

    Main Methods:

    • * Review of established mouse mating schemes for aneuploidy induction.
    • * Analysis of techniques producing various aneuploid states (trisomy, partial trisomy, monosomy).

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  • * Compilation of data on developmental outcomes associated with specific autosomal trisomies.

    • Main Results:

    • * Specific mating strategies can efficiently generate aneuploid mouse conceptuses.
    • * Autosomal trisomy is the most frequently observed aneuploid condition.
    • * Various autosomal trisomies in mice are associated with distinct developmental consequences.

    Conclusions:

    • * Developed mouse models provide valuable tools for studying aneuploidy.
    • * Understanding developmental impacts of aneuploidy is crucial for reproductive biology research.
    • * This review consolidates knowledge on mouse aneuploidy models and their consequences.