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Published on: March 26, 2020
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Towards standardizing retinal optical coherence tomography angiography: a review.
Danuta M Sampson1, Adam M Dubis2, Fred K Chen3,4,5
1Surrey Biophotonics, Centre for Vision, Speech and Signal Processing and School of Biosciences and Medicine, The University of Surrey, Guildford, GU2 7XH, UK. danuta.sampson@surrey.ac.uk.
Light, Science & Applications
|March 19, 2022
Summary
Standardizing optical coherence tomography angiography (OCTA) imaging protocols is crucial for advancing retinal disease research and diagnosis. This paper proposes minimum standards to overcome inconsistencies and facilitate large-scale data analysis for improved patient care.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biomedical Engineering
Background:
- Retinal microvasculature assessment is vital for diagnosing and monitoring ocular and systemic diseases.
- Optical coherence tomography angiography (OCTA) enables volumetric, contrast-agent-free visualization of retinal microvasculature.
- Inconsistent imaging protocols and lack of data sharing hinder OCTA's clinical application and research progress.
Purpose of the Study:
- To address limitations in OCTA application by proposing standardization of human retinal imaging.
- To identify and resolve inconsistencies in current OCTA imaging protocols, data analysis, and metrics.
- To encourage data sharing and cross-comparison for building comprehensive OCTA image databases.
Main Methods:
- Comprehensive review of existing OCTA literature to identify issues and inconsistencies.
- Proposal of minimum standards for OCTA imaging protocols, data analysis, metrics, and reporting.
- Identification of areas requiring further investigation for future standardization efforts.
Main Results:
- Identified significant inconsistencies in OCTA imaging and analysis methods across studies.
- Proposed a framework for standardized OCTA imaging protocols and data reporting.
- Highlighted the need for open data sharing and collaborative research initiatives.
Conclusions:
- Standardization of OCTA imaging is essential for reliable diagnosis, monitoring, and research of retinal diseases.
- Adoption of proposed minimum standards will promote transparency and facilitate larger, more robust studies.
- Unification of OCTA protocols will enhance its impact on retinal healthcare and life science investigations.
