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Updated: Sep 29, 2025
10:46
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
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SARS-CoV-2 triggered relapse of multiple sclerosis.
1Neurology & Neurophysiology Center, Vienna, Austria.
Clinical Neurology and Neurosurgery
|March 19, 2022
Summary
A mild COVID-19 infection in a patient with relapsing remitting multiple sclerosis (RRMS) triggered a disease relapse, indicating a potential link between SARS-CoV-2 and neuro-immunological exacerbations. Neurologists should monitor patients for such events post-infection.
Area of Science:
- Neuroscience
- Immunology
- Infectious Diseases
Background:
- Emerging evidence suggests SARS-CoV-2 may precipitate new or relapsing neuro-immunological conditions.
- Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
Observation:
- A 27-year-old female with relapsing-remitting MS (RRMS) on disease-modifying therapy (DMT) experienced a relapse two weeks after a mild COVID-19 infection.
- Imaging revealed increased thoracic spine lesion load and a new enhancing lesion, indicating active disease progression.
Findings:
- The patient's RRMS exacerbated following SARS-CoV-2 infection, despite being on DMT.
- Treatment with steroids and a change in DMT led to clinical improvement.
- The patient tolerated SARS-CoV-2 vaccination six months post-infection.
Implications:
- SARS-CoV-2 infection may lead to MS exacerbation and potential DMT failure.
- A causal relationship between SARS-CoV-2 and MS relapse is plausible.
- Clinicians must maintain vigilance for neuro-immunological disease activity after SARS-CoV-2 infection.
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