Seeing the forest through the trees: characterizing the glycoproteome
Related Experiment Video
Updated: Sep 29, 2025

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
Published on: February 7, 2025
Meg Critcher1, Abdullah A Hassan2, Mia L Huang3
1Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA; Department of Molecular Medicine, Scripps Research, 120 Scripps Way, Jupiter, FL 33458, USA; Department of Molecular Medicine, Scripps Research, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.
Abstract:
Post-translational modifications (PTMs) immensely expand the diversity of the proteome. Glycosylation, among the most ubiquitous PTMs, is a dynamic and multifarious modification of proteins and lipids that generates an omnipresent foliage on the cell surface. The resulting protein glycoconjugates can serve important functions in biology. However, their vast complexity complicates the study of their structures, interactions, and functions. There is now a growing appreciation of the need to study glycans and proteins together as complete entities, as the sum of these two components can exhibit unique functions. In this review, we discuss the growing forestry toolbox to characterize the structure, interactions, and biological functions of protein glycoconjugates, as well as the potential payouts of understanding and controlling these enigmatic biomolecules.
Related Concept Videos
Protein Glycosylation
Glycosylation occurs in...
Proteomics
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Proteoglycans
Matrix Proteoglycans and Glycoproteins
Glycocalyx and its Functions

