Ejaculatory Function Following Stereotactic Body Radiation Therapy for Prostate Cancer

Area of Science:

• Oncology
• Radiation Oncology
• Urology

Background:

• Ejaculatory dysfunction is a significant quality of life concern for men.
• This issue has not been extensively studied in the context of prostate stereotactic body radiation therapy (SBRT).

Purpose of the Study:

• To evaluate changes in ejaculatory function after prostate SBRT.

Main Methods:

• A prospective quality of life study included 231 patients treated with prostate SBRT (2013-2019).
• Ejaculatory function was assessed using the Ejaculation Scale (ES-8) at multiple time points up to 24 months post-treatment.
• Patients aged over 70 and those receiving hormonal therapy were excluded.

Main Results:

• The 2-year anejaculation rate was 15%.
• Mean ES-8 scores declined in the first month post-SBRT and then stabilized.
• Patient-reported ejaculate volume was significantly reduced, and ejaculatory discomfort peaked at 1 and 9 months post-SBRT.

Conclusions:

• Prostate SBRT can lead to meaningful changes in ejaculatory function.
• Patients should be informed about the potential trajectory of these side effects.
• Further research into novel approaches for improving ejaculation is warranted.