Non-metastatic castration-resistant prostate cancer: management recommendations

Area of Science:

• Oncology
• Urology

Background:

• Non-metastatic castration-resistant prostate cancer (nmCRPC) significantly impacts patient survival and quality of life (QoL) upon metastasis development.
• Newer generation antiandrogens demonstrate potential in prolonging metastasis-free survival (MFS) and overall survival (OS).

Purpose of the Study:

• To establish consensus-based recommendations for managing nmCRPC patients in urology consultations.
• To consolidate and improve current clinical practices for nmCRPC management.

Main Methods:

• A systematic literature review was conducted by a scientific committee.
• Consensus was reached on practical recommendations for nmCRPC patient care.

Main Results:

• Recommendations cover PSA determination and imaging frequency for nmCRPC.
• The review highlights the significance of comorbidities and QoL assessment in nmCRPC management.
• Efficacy, safety, and QoL effects of new antiandrogens were evaluated.

Conclusions:

• Effective nmCRPC treatment requires consideration of comorbidities and QoL alongside age.
• New generation antiandrogens represent a safe and effective therapeutic choice for nmCRPC.
• The provided recommendations can optimize the management of nmCRPC patients in clinical settings.