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Design, synthesis and structure-activity relationship studies of pyrido[2,3-d]pyrimidin-7-ones as potent Janus Kinase

Wenhong Su1, Zhiwen Chen2, Meiying Liu3

  • 1Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China; Nano Science and Technology Institute, University of Science and Technology of China, Suzhou 215123, China.

Bioorganic & Medicinal Chemistry Letters
|March 20, 2022
PubMed

Keywords:
Anti-cancer activityCovalent inhibitorJAK3Selectivity

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