Related Experiment Video
Updated: Sep 29, 2025
Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
Published on: June 21, 2024
The effect of using an interactive mobile application for the management of chemotherapy-induced nausea and vomiting
Remziye Semerci1, Melahat Akgün Kostak2, Cem Taşkın3
1Koç University, School of Nursing, Department of Pediatric Nursing, Topkapı, 34010, İstanbul, Turkey.
Insights
A new mobile app, 5inD, effectively reduced chemotherapy-induced nausea and vomiting (CINV) in pediatric patients. The app showed greater success in managing acute CINV compared to delayed CINV.
Area of Science:
- Pediatric Oncology
- Digital Health Interventions
- Symptom Management
Background:
- Chemotherapy-induced nausea and vomiting (CINV) significantly impacts pediatric cancer patients' quality of life.
- Existing CINV management strategies require innovative, patient-centered approaches.
Purpose of the Study:
- To develop and evaluate the efficacy of an interactive mobile application, 5inD, for managing CINV in pediatric oncology patients.
- To assess the impact of 5inD on both acute and delayed CINV symptoms.
Main Methods:
- A prospective, randomized controlled trial involving 57 children (aged 8-18) undergoing chemotherapy.
- Development of the 5inD mobile application incorporating five distraction techniques.
- Data collection using the Adapted Rhodes Index for Nausea & Vomiting child (ARINVc) and parent (ARINVp) versions over seven days.
Main Results:
- The 5inD intervention group demonstrated significantly lower ARINVc and ARINVp scores compared to the control group.
- Statistically significant differences were observed in group, time, and group*time interactions for both child and parent-reported CINV.
- The mobile application was more effective in reducing acute CINV than delayed CINV.
Conclusions:
- The interactive mobile application 5inD is an effective tool for reducing CINV in pediatric oncology patients.
- 5inD shows promise as a supportive care technology for improving treatment experience in children with cancer.
- The application's effectiveness is more pronounced for acute CINV management.
Purpose:
This study was conducted to develop an interactive mobile application called 5inD, and investigate the effect of 5inD on the management of chemotherapy-induced nausea and vomiting (CINV) in pediatric oncology patients.
Methods:
The prospective, parallel-group and randomized controlled study was conducted in a university hospital between October 2019 and January 2021 with 57 children aged 8-18 years who were treated with chemotherapy and their mothers. In this study, a mobile application called "5inD" was developed, which includes five distraction methods to reduce CINV. Data were collected about CINV through the Adapted Rhodes Index for Nausea & Vomiting child version (ARINVc), and parent version (ARINVp). CINV of the children was evaluated for seven days starting from the first day of chemotherapy.
Results:
In the study, Child ARINVc and Parent ARINVp mean scores of the intervention groups were lower than the control group during the seven days (p < 0.05). There was a statistically significant difference between the group's Adapted Rhodes Index of Nausea and Vomiting for Pediatrics by Child (ARINVc) and by Parent (ARINVp) mean scores in terms of the group, time, and group*time interaction. While a statistically significant difference was found between the intervention group's and control group's mean scores in terms of the group, time, and group*time for the acute CINV (p < 0.05), there was no statistically significant difference for delayed CINV between groups scores in terms of the time, and group*time interaction (p > 0.05).
Conclusion:
This study supports the findings that the interactive mobile application was found effective in reducing CINV in children. Additionally, it can be said 5inD is more effective for the management of acute CINV than delayed CINV.
Related Concept Videos
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
01:29Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...