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Updated: Sep 29, 2025

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
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Annealing Temperature-Dependent Surface-Enhanced Raman spectroscopy on MoS2-Covered silver nanoparticle array.

Muhua Li1, Yanqi Liu1, Xuan Liu2

  • 1Institute of Laser Engineering, Faculty of Materials and Manufacturing, Beijing University of Technology, Beijing 100124, China.

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
|March 20, 2022
PubMed
Summary

Researchers developed a novel 2D material/metallic hybrid substrate using molybdenum disulfide (MoS2) and silver nanoparticles (AgNPs) for ultra-sensitive surface-enhanced Raman spectroscopy (SERS). This hybrid substrate achieves a detection limit of 10⁻¹³ M, showing great potential for chemical detection.

Keywords:
2D materialsAnnealing temperatureSERSSilver nanoparticle array

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Surface-enhanced Raman spectroscopy (SERS) offers ultra-sensitive molecular detection via vibrational fingerprints.
  • Developing stable, sensitive, and reproducible SERS substrates remains a significant challenge for practical applications.
  • Two-dimensional (2D) materials combined with metallic nanostructures present a promising avenue for enhancing SERS performance.

Purpose of the Study:

  • To fabricate and characterize a high-performance SERS substrate using a monolayer molybdenum disulfide (MoS2) covered silver nanoparticle (AgNP) array.
  • To investigate the effect of annealing temperature on the SERS performance of the MoS2/AgNPs hybrid substrate.
  • To evaluate the potential applications of the developed substrate in food safety and biochemical environmental detection.

Main Methods:

  • Fabrication of a hybrid SERS substrate comprising a monolayer MoS2 film and an array of AgNPs.
  • Systematic exploration of annealing temperature effects on SERS signal intensity and substrate performance.
  • Characterization of substrate morphology, nanoparticle distribution, and contact interface using relevant techniques.

Main Results:

  • Optimal SERS performance was achieved at an annealing temperature of 290 °C.
  • The optimized substrate exhibited a detection limit of 10⁻¹³ M for Rhodamine 6G with a SERS enhancement factor of 8.3 × 10⁹.
  • Enhanced performance is attributed to improved AgNP-MoS2 contact and uniform AgNPs with optimal particle size.

Conclusions:

  • The MoS2/AgNPs hybrid substrate demonstrates superior sensitivity, stability, and reproducibility for SERS applications.
  • The optimized annealing process is crucial for maximizing the SERS enhancement.
  • The developed substrate shows significant potential for sensitive detection in food safety and environmental monitoring.