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MEFV Mutations in IBD Patients: A Systematic Review and Meta- analysis
Vasileios P Papadopoulos1, Christina Antoniadou2, Konstantinos Ritis3
1First Department of Internal Medicine and Laboratory of Molecular Hematology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis; Department of Internal Medicine, Xanthi General Hospital, Xanthi, Greece. . vaspapmd@gmail.com.
Mutations in the MEFV gene, linked to familial Mediterranean fever (FMF), are common in inflammatory bowel disease (IBD) patients. These mutations correlate with extra-intestinal issues and pancolitis in IBD.
Area of Science:
- Genetics
- Gastroenterology
- Molecular Biology
Background:
- Familial Mediterranean Fever (FMF) gene (MEFV) mutations are increasingly noted in inflammatory bowel disease (IBD) patients.
- This study investigates the correlation between MEFV gene mutations and IBD prevalence and characteristics.
Approach:
- A systematic review and meta-analysis of thirteen observational studies published up to January 2021.
- Included studies analyzed MEFV mutation patterns in ulcerative colitis (UC), Crohn's disease (CD), and indeterminate colitis (IC) patients versus controls.
- Study quality was assessed using the Newcastle-Ottawa scale.
Key Points:
- MEFV mutations were more frequent in IBD patients (0.238) compared to controls (p<0.05 for UC, CD, IC).
- Indeterminate colitis showed a higher prevalence of MEFV mutations (p<0.001).
- MEFV mutations were associated with extra-intestinal manifestations (OR 2.57) and pancolitis (OR 2.02). Exon 10 mutations had the most significant impact.
Conclusions:
- MEFV mutations are prevalent in IBD and associated with specific clinical features.
- Further research is needed to understand the clinical and evolutionary significance of MEFV mutations in IBD.
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