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Updated: Sep 29, 2025

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Multiple roles of m6A methylation in epithelial-mesenchymal transition
Xueru Zhao1,2,3,4, Xue Li1,2,3,4, Xiaohua Li5,6,7,8
1Henan Provincial People's Hospital, NO.7 Weiwu Road, Zhengzhou, 450003, China.
Abstract:
Epithelial-mesenchymal transition (EMT) plays an important role in migration and invasion of cancer cell and the development of tissue fibrosis diseases. N6-methyladenosine (m6A) is the most extensive type of RNA methylation and has aroused extensive interest in recent years. However, m6A methylation seems to play different roles in different cancer cells and tissue fibrotic diseases. To determine the function of m6A methylation in EMT, we summarized the molecular mechanism of EMT and recent progress in the regulation of EMT by m6A methylation, suggesting that m6A methylation targets EMT program by affecting the expression of transcription factors, EMT markers, long noncoding RNA and EMT-associated signaling pathways, which provides more possibilities for early diagnosis and treatment.
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