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Updated: Sep 29, 2025
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Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
Published on: August 1, 2018
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Clinical parameters associated with gastric portal hypertensive polyps
Florian Freimut Hildenbrand1, Chantal Wohlwend1, Stefanie von Felten2
1Division of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.
Scandinavian Journal of Gastroenterology
|March 21, 2022
Summary
Portal hypertensive polyps (PHPs) are more common than previously thought and often misdiagnosed. Previous rubber band ligation and increased liver stiffness are linked to their appearance.
Area of Science:
- Gastroenterology
- Hepatology
- Pathology
Background:
- Portal hypertensive polyps (PHPs) are uncommon gastric lesions associated with portal hypertension.
- Their clinical factors and prevalence are not well-established.
Purpose of the Study:
- To determine the prevalence of PHPs in cirrhotic patients.
- To identify clinical factors associated with PHP appearance.
Main Methods:
- A cross-sectional study of 513 cirrhotic patients.
- Descriptive analyses and multivariable logistic regression were used.
- Multiple imputation addressed missing data for HVPG and liver stiffness.
Main Results:
- PHP prevalence was 3.3%, with 53% misclassified during initial gastroscopy.
- Patients with PHPs were older and had higher HVPG, liver stiffness (TE), and prior RBL.
- Multivariable analysis showed RBL (OR 3.84) and liver stiffness (OR 1.03) significantly correlated with PHPs.
Conclusions:
- PHP prevalence is higher than previously reported, with frequent misclassification.
- PHPs are associated with prior RBL and may indicate severe portal hypertension.
- PHPs could serve as a marker for significant portal hypertension, though their clinical significance requires further study.
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