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The Effects of Increased Glucose Level and Glycolysis on SARS CoV-2 Infection

Fatma Ozlem Zurnaci1,2, Mustafa Guzel1,3,4

  • 1Research Institute for Health Sciences and Technologies (SABITA), Center of Drug Discovery and Development, Istanbul Medipol University, Kavacik-Beykoz / Istanbul, 34810, Turkey.

Mini Reviews in Medicinal Chemistry
|March 21, 2022
PubMed

Insights

Investigating glycolysis inhibitors for COVID-19 treatment shows promise. Targeting increased glycolysis and high glucose levels may improve patient survival rates for this critical illness.

Area of Science:

  • Biochemistry
  • Virology
  • Pharmacology

Background:

  • COVID-19 remains a global health threat with significant mortality.
  • Vaccination has helped, but effective treatments are still needed.
  • Elevated glycolysis is observed in COVID-19 patients.

Purpose of the Study:

  • To review the potential benefits of inhibiting glycolysis in COVID-19.
  • To explore controlling elevated glucose levels in COVID-19 patients.

Main Methods:

  • Literature review of studies on COVID-19 metabolism.
  • Analysis of the role of glycolysis in viral infections.
  • Examination of potential therapeutic strategies targeting glucose metabolism.

Main Results:

  • Increased glycolysis is a metabolic hallmark of severe COVID-19.
  • Glycolysis inhibitors may offer a novel therapeutic approach.
  • Controlling hyperglycemia is crucial for patient outcomes.

Conclusions:

  • Inhibiting glycolysis presents a promising strategy for COVID-19 treatment.
  • Targeting metabolic pathways could improve survival rates.
  • Further research into glycolysis inhibitors is warranted.
Keywords:
Antiviral researchCOVID-19 treatmentSARS-CoV-2diabetesglucose levelglycolysis inhibition

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