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Updated: Sep 29, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Medical management of severe obstructive sleep apnoea in two cases during the coronavirus disease 2019 pandemic
H S Gajaweera1, C Griffiths1, L H Everitt1
1Paediatric Respiratory Department, Southampton Children's Hospital, Southampton, UK.
Insights
Continuous positive airway pressure (CPAP) therapy was poorly tolerated in children with severe obstructive sleep apnoea due to adenotonsillar hypertrophy. Surgery remains the most effective treatment for this condition.
Area of Science:
- Pediatric Otolaryngology
- Sleep Medicine
- Respiratory Medicine
Background:
- Severe pediatric obstructive sleep apnea (OSA) in children with adenotonsillar hypertrophy is typically treated with surgery.
- During the COVID-19 pandemic, non-emergency ENT surgeries were paused, leading to the use of medical management for pediatric OSA.
Purpose of the Study:
- To evaluate the effectiveness of continuous positive airway pressure (CPAP) combined with medical management for severe pediatric OSA when surgery was unavailable.
Main Methods:
- A service evaluation was conducted over five months in 2020.
- Two children with severe OSA secondary to adenotonsillar hypertrophy were offered CPAP and medical treatments.
Main Results:
- Both children failed to tolerate CPAP therapy due to disturbed sleep.
- Both children subsequently underwent adenotonsillectomy, leading to improved Sleep-Related Breathing Disorder scale scores.
Conclusions:
- CPAP therapy is poorly tolerated in children with severe OSA caused by adenotonsillar hypertrophy.
- Surgical intervention, such as adenotonsillectomy, remains the most appropriate and effective treatment for this condition.
Objective:
Severe paediatric obstructive sleep apnoea in typically developing children with adenotonsillar hypertrophy is primarily managed surgically. Non-emergency ENT surgery was paused early in the coronavirus disease 2019 pandemic and children were offered medical management for obstructive sleep apnoea.
Methods:
A service evaluation was performed to assess the impact of continuous positive airway pressure alongside medical management for severe obstructive sleep apnoea.
Results:
Over 5 months during 2020, in a tertiary care setting, two children (one boy and one girl), aged 2.7 years and 4.1 years, were offered continuous positive airway pressure and medical treatments for severe obstructive sleep apnoea whilst surgery was paused during the coronavirus disease 2019 pandemic. Both children failed to establish continuous positive airway pressure therapy because of ongoing disturbed sleep on ventilation, and they proceeded to adenotonsillectomy. Sleep-Related Breathing Disorder scale scores improved following surgical intervention.
Conclusion:
Continuous positive airway pressure therapy is poorly tolerated in children with severe obstructive sleep apnoea secondary to adenotonsillar hypertrophy. Surgery remains the most appropriate treatment.
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