Symptom-related Ki-67 expression in endometrial polyps

Area of Science:

• Gynecology
• Pathology
• Oncology

Background:

• Endometrial polyps are common causes of abnormal uterine bleeding (AUB).
• Ki-67 is a marker of cellular proliferation.
• The relationship between Ki-67 expression and AUB patterns in endometrial polyps requires further investigation.

Purpose of the Study:

• To compare Ki-67 expression levels in endometrial polyps.
• To correlate Ki-67 expression with different types of abnormal uterine bleeding (AUB).
• To assess the predictive value of Ki-67 for treatment outcomes.

Main Methods:

• A prospective study included 120 women with endometrial polyps.
• Tissue samples were obtained via hysteroscopic polypectomy.
• Immunohistochemical analysis quantified Ki-67 glandular and stromal expression.

Main Results:

• Ki-67 expression was significantly higher in premenopausal women compared to postmenopausal women.
• Higher Ki-67 levels were observed in patients with heavy menstrual bleeding (HMB) and intermenstrual bleeding (IMB).
• Increased Ki-67 stromal expression correlated with persistent AUB after polypectomy, with a cutoff of ≤6% for predicting treatment response.

Conclusions:

• High Ki-67 expression in endometrial polyps is linked to HMB.
• Ki-67 may serve as a biomarker to predict the persistence of AUB following polypectomy.