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Management of Hypertrophic Cardiomyopathy in a Newborn with Dextro-Transposition of the Great Arteries

Amee M Bigelow1, Molly K Ball2, Mark Galantowicz3

  • 1Department of Pediatrics, The Heart Center, Nationwide Children's Hospital, The Ohio State University, 700 Children's Drive, Columbus, OH, 43205, USA. amee.bigelow@nationwidechildrens.org.

Pediatric Cardiology
|March 21, 2022
PubMed

Insights

Maternal diabetes can cause fetal heart defects like dextro-transposition of the great arteries and hypertrophic cardiomyopathy. Early diagnosis and multidisciplinary care are crucial for positive outcomes in these rare cases.

Area of Science:

  • Cardiovascular Science
  • Developmental Biology
  • Maternal-Fetal Medicine

Background:

  • Impaired maternal glucose metabolism impacts fetal cardiovascular development.
  • Teratogenic effects can cause structural heart defects early in pregnancy.
  • Fetal hyperinsulinism later in gestation may lead to hypertrophic cardiomyopathy.

Purpose of the Study:

  • To describe an infant with dextro-transposition of the great arteries and hypertrophic cardiomyopathy.
  • To highlight the importance of a multidisciplinary approach for rare cardiac malformations.

Main Methods:

  • Case report of an infant with complex congenital heart disease.
  • Longitudinal follow-up from fetal diagnosis through post-operative management.

Main Results:

  • The infant presented with dextro-transposition of the great arteries and hypertrophic cardiomyopathy.
  • A comprehensive, multidisciplinary approach facilitated an excellent outcome.

Conclusions:

  • Early and accurate diagnosis of fetal cardiac malformations is essential.
  • Integrated, multidisciplinary care improves outcomes for infants with complex congenital heart disease.

Keywords:
Critical care managementFetal diagnosisHypertrophic cardiomyopathyPrenatal multidisciplinary approachTransposition of the great arteries

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