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Updated: Sep 29, 2025

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Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
Published on: December 17, 2019
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CD4+ chimeric antigen receptor T cells in for the long journey
Amanda Xy Chen1,2, Emily B Derrick1,2, Paul A Beavis1,2
1Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Immunology and Cell Biology
|March 21, 2022
Abstract:
In a recently published article, Melenhorst et al. performed a longitudinal analysis on chimeric antigen receptor (CAR) T cells isolated from patients over 10 years after therapy, revealing expansion of a long-lived CD4+ CAR T-cell population with a cytotoxic phenotype.

