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Updated: Sep 29, 2025
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
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Glutathione-Responsive Heterogeneous Metal-Organic Framework Hybrids for Photodynamic-Gene Synergetic Cell Apoptosis
Jintong Liu1,2, Bernardino J Córdova Wong1, Tianrui Liu1
1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, P. R. China.
Abstract:
A core-shell heterogeneous metal-organic framework (MOF) hybrid is sequentially designed by a photosensitized porous coordination network (PCN)-typed MOF as core and Cu2+ -centered zeolitic imidazolate framework (ZIF-67) as shell encapsulating cyanine 3-labelled siRNA. The heterogeneous MOF hybrid realized stimulus-responsive photodynamic therapy (PDT) and controllable siRNA delivery through 1 O2 -assistant endosomal escape for imaging-guided photodynamic-gene synergetic theranostics.
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