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Updated: Sep 29, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

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Rapidly progressive crescentic diabetic nephropathy: two case reports.

Jade E Schroers1, Alexander M Gilbert1, Paul R McKenzie2

  • 1Kidney Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Internal Medicine Journal
|March 21, 2022
PubMed
Summary

Diabetic nephropathy rarely shows crescents, but two patients developed them alongside rapid kidney function decline and nephrotic syndrome. Renal biopsy confirmed these crescents in late-stage diabetic kidney disease, suggesting a potential link.

Keywords:
biopsychronic kidney diseasecrescentdiabetic nephropathynephrotic syndrome

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Area of Science:

  • Nephrology
  • Pathology
  • Diabetology

Background:

  • Diabetic nephropathy is a leading cause of chronic kidney disease.
  • Renal crescents are typically associated with other forms of glomerulonephritis.
  • The presence of crescents in diabetic nephropathy is not widely recognized.

Observation:

  • Two cases presented with acute kidney injury and nephrotic syndrome.
  • Standard glomerulonephritis workup was negative.
  • Renal biopsy revealed non-necrotizing cellular crescents.

Findings:

  • Biopsies showed features consistent with advanced diabetic nephropathy.
  • Cellular crescents were identified in the glomeruli.
  • This challenges the traditional understanding of diabetic nephropathy presentation.

Implications:

  • The findings suggest crescents may occur in diabetic nephropathy.
  • Further research is needed to understand the mechanisms and clinical significance.
  • This could impact diagnostic and treatment strategies for diabetic kidney disease.