Natural Products Against Renal Fibrosis via Modulation of SUMOylation
Peng Liu1, Jing Zhang2, Yun Wang1
1Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, China.
Abstract:
Renal fibrosis is the common and final pathological process of kidney diseases. As a dynamic and reversible post-translational modification, SUMOylation and deSUMOylation of transcriptional factors and key mediators significantly affect the development of renal fibrosis. Recent advances suggest that SUMOylation functions as the promising intervening target against renal fibrosis, and natural products prevent renal fibrosis via modulating SUMOylation. Here, we introduce the mechanism of SUMOylation in renal fibrosis and therapeutic effects of natural products. This process starts by summarizing the key mediators and enzymes during SUMOylation and deSUMOylation and its regulation role in transcriptional factors and key mediators in renal fibrosis, then linking the mechanism findings of SUMOylation and natural products to develop novel therapeutic candidates for treating renal fibrosis, and concludes by commenting on promising therapeutic targets and candidate natural products in renal fibrosis via modulating SUMOylation, which highlights modulating SUMOylation as a promising strategy for natural products against renal fibrosis.
Insights
SUMOylation, a reversible modification, plays a key role in kidney fibrosis. Natural products that modulate SUMOylation show promise as therapeutic agents for treating renal fibrosis.
Area of Science:
- Biochemistry
- Nephrology
- Pharmacology
Background:
- Renal fibrosis is a common endpoint for chronic kidney diseases.
- SUMOylation and deSUMOylation are dynamic post-translational modifications influencing renal fibrosis progression.
- Targeting SUMOylation pathways presents a potential therapeutic strategy for kidney diseases.
Purpose of the Study:
- To elucidate the mechanism of SUMOylation in renal fibrosis.
- To explore the therapeutic potential of natural products in modulating SUMOylation for treating renal fibrosis.
- To identify novel therapeutic targets and natural product candidates for renal fibrosis.
Main Methods:
- Summarizing key mediators and enzymes in SUMOylation and deSUMOylation pathways.
- Analyzing the regulatory role of SUMOylation in transcriptional factors and mediators of renal fibrosis.
- Linking SUMOylation mechanisms with the effects of natural products.
Main Results:
- SUMOylation and deSUMOylation significantly impact the development of renal fibrosis.
- Natural products demonstrate efficacy in preventing renal fibrosis by modulating SUMOylation.
- Specific mediators and transcriptional factors involved in SUMOylation pathways were identified.
Conclusions:
- Modulating SUMOylation is a promising therapeutic strategy against renal fibrosis.
- Natural products offer potential candidates for novel renal fibrosis treatments targeting SUMOylation.
- Further research into SUMOylation pathways can lead to the development of effective therapies for kidney diseases.
