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Collapsing Glomerulopathy: A Review by the Collapsing Brazilian Consortium
Érico Murilo Monteiro Cutrim1, Precil Diego Miranda de Meneses Neves2, Marcos Adriano Garcia Campos3
1University Hospital, Federal University of Maranhão, São Luís, Brazil.
Frontiers in Medicine
|March 21, 2022
Summary
Collapsing glomerulopathy (CG), a severe kidney disease, is linked to APOL1 gene mutations and viral infections. This review highlights its distinct podocytopathy and worse prognosis compared to other focal segmental glomerulosclerosis subtypes.
Area of Science:
- Nephrology
- Pathology
- Genetics
Background:
- Collapsing glomerulopathy (CG) is a kidney disease characterized by glomerular collapse and podocyte proliferation.
- Classified as a subtype of focal segmental glomerulosclerosis (FSGS), CG shows a higher prevalence in certain populations, particularly those of African descent.
- CG is recognized as a distinct podocytopathy with unique pathogenic mechanisms.
Purpose of the Study:
- To conduct a narrative review of populational studies on collapsing glomerulopathy.
- To synthesize current knowledge on CG's epidemiology, risk factors, clinical presentation, and prognosis.
Main Methods:
- A narrative review of articles published in PubMed, Medline, and Scielo databases.
- Search conducted from September 1, 2020, to December 31, 2021.
- Focus on populational studies, including cross-sectional and cohort designs.
Main Results:
- Significant risk factors for CG include APOL1 gene mutations and infections with HIV and SARS-CoV-2.
- CG typically presents with severe symptoms and substantial renal damage.
- The prognosis for CG is considerably worse than for other FSGS subtypes.
Conclusions:
- Collapsing glomerulopathy is a severe podocytopathy with significant risk factors and a poor prognosis.
- Further research into CG pathogenesis and management is warranted, especially in at-risk populations.