Related Experiment Video

Updated: Sep 29, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K

Crucial Roles of miR-625 in Human Cancer

Menggang Zhang1,2,3,4, Fei Xiong1,2,3,4, Shuijun Zhang1,2,3,4

  • 1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in Medicine
|March 21, 2022
PubMed

Insights

MicroRNAs (miRNAs) like miR-625 play a key role in cancer development by regulating gene expression. Abnormal miR-625 expression is linked to various cancers, impacting cell processes and treatment resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Genetic and epigenetic factors are fundamental to cancer development.
  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • Emerging evidence highlights miRNAs' critical roles in human cancer initiation and progression.

Purpose of the Study:

  • To review the aberrant expression of miR-625 across diverse cancer types.
  • To elucidate the molecular mechanisms underlying miR-625's involvement in tumorigenesis.
  • To explore the potential of miR-625 in cancer diagnostics, therapeutics, and prognostics.

Main Methods:

  • Literature review focusing on miR-625 expression and function in various cancers.
  • Analysis of miR-625's role in biological processes including proliferation, invasion, migration, apoptosis, cell cycle, and drug resistance.
  • Examination of regulatory networks involving long non-coding RNAs (lncRNAs), miRNAs, and messenger RNAs (mRNAs), including competing endogenous RNA (ceRNA) mechanisms.

Main Results:

  • miR-625 exhibits abnormal expression patterns in numerous human cancers.
  • miR-625 significantly influences key cancer-related biological processes.
  • lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA networks, mediated by ceRNAs, are implicated in miR-625's regulatory functions.

Conclusions:

  • miR-625 is a crucial regulator in various cancers, affecting critical cellular functions.
  • The study highlights miR-625's potential as a biomarker for cancer diagnosis and prognosis.
  • miR-625 presents promising therapeutic implications for clinical cancer management.
Keywords:
cancerceRNAmiR-625proliferationtherapeutic target

More Related Videos

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

17.7K
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.5K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.2K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.0K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.7K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.3K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
5.2K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.4K