Related Experiment Video

Updated: Sep 29, 2025

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
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Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

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Reduced CCR2 Can Improve the Prognosis of Sarcoma by Remodeling the Tumor Microenvironment

Baixing Wei1, Hao Feng1, Han Wu1

  • 1Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, People's Republic of China.

International Journal of General Medicine
|March 21, 2022
PubMed
Abstract

Insights

Researchers identified CCR2 as a key regulator of the tumor microenvironment (TME) in sarcoma (SARC). Targeting CCR2 may offer new therapeutic strategies for SARC by remodeling the TME and enhancing immunotherapy.

Area of Science:

  • Oncology
  • Immunology
  • Bioinformatics

Background:

  • The tumor microenvironment (TME) is crucial in sarcoma (SARC) development.
  • Effective regulation of the SARC TME remains a challenge.

Purpose of the Study:

  • Identify core molecules regulating both immune and stromal cells within the TME.
  • Determine potential therapeutic targets for SARC.

Main Methods:

  • Utilized ESTIMATE algorithm to assess immune and stromal components in 265 SARC samples.
  • Employed protein-protein interaction (PPI) network, COX, survival, and GSEA analyses to identify prognostic genes.
  • Applied CIBERSORT and xcell algorithms to quantify immune and stromal cell infiltration.

Main Results:

  • Increased immune and stromal components in the TME correlated with poor SARC prognosis.
  • Identified CCR2 as a core prognostic gene regulating both immune and stromal cells.
  • CCR2 was found to regulate 12 immune cell types and 7 stromal cell types, including key cells like CD4+ T cells, CD8+ T cells, MSCs, and fibroblasts.

Conclusions:

  • CCR2 plays a significant prognostic role in the SARC TME.
  • CCR2 is a potential therapeutic target for TME remodeling and immunotherapy in SARC.
Keywords:
CCR2immunitymacrophagesstromal cellstumor microenvironment

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