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Human infections with neglected vector-borne pathogens in China: A systematic review
Yan-Qun Sun1,2, Tao Wang1, Yuan-Yuan Zhang1
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dong-Da Street, Fengtai District, Beijing 100071, China.
The Lancet Regional Health. Western Pacific
|March 21, 2022
Summary
This review identified 82 vector-borne pathogens (VBPs) causing human illness in China, with Rickettsiales bacteria being most common. Findings highlight the need for enhanced VBP surveillance and research in diverse settings.
Area of Science:
- Medical Entomology
- Infectious Diseases
- Public Health Microbiology
Background:
- Emerging vector-borne pathogens (VBPs) represent a significant global health threat.
- Comprehensive data on VBP distribution and epidemiology are lacking in many regions, including China.
- Novel VBP outbreaks are of increasing international concern.
Purpose of the Study:
- To systematically review and characterize the spectrum of VBPs causing human illness in China.
- To identify the most prevalent VBPs and their geographical distribution.
- To inform future research and surveillance strategies for VBPs in China.
Main Methods:
- A systematic review of published literature from January 1980 to June 2021 was conducted.
- Five databases were searched for VBP-related articles in English and Chinese, excluding those in China's National Notifiable Diseases Surveillance System.
- Data from 906 included articles were analyzed, with a meta-analysis performed on clinical information from 419 articles.
Main Results:
- A total of 44,809 human infections with 82 VBP species (40 viruses, 33 bacteria, 9 parasites) were identified.
- Rickettsiales bacteria were the most common (18,042 cases), followed by Spirochaetales bacteria (15,745 cases).
- Eighteen novel VBPs were reported, with flu-like illness being the most common clinical manifestation.
Conclusions:
- This review enhances the understanding of VBPs circulating in China.
- Findings underscore the necessity for broader VBP surveillance across various settings.
- The study provides a foundation for targeted future research and improved public health interventions.
