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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K

Nontraditional risk factors in chronic kidney disease: correlation between creatinine clearance, Framingham risk

Ahmed Mohamed Tawfik1, Heba Mohamed Tawfik2

  • 1Internal Medicine & Nephrology department, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.

The Egyptian Journal of Internal Medicine
|March 21, 2022
PubMed

Insights

Chronic kidney disease is linked to poor vascular function and increased cardiovascular risk. This study highlights the connection between declining kidney function, inflammation, and atherosclerosis in patients with chronic kidney disease.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Biology

Background:

  • Chronic kidney disease (CKD) presents a significant public health challenge, increasing healthcare costs.
  • Understanding the interplay between cardiovascular risk, endothelial dysfunction, inflammation, and kidney function is crucial for CKD patients.

Purpose of the Study:

  • To investigate the relationship between cardiovascular risk factors, endothelial dysfunction, inflammation, and kidney function in patients with CKD.
  • To identify non-traditional factors contributing to the decline in kidney function.

Main Methods:

  • A cross-sectional study involving 30 CKD patients (stages 3-5).
  • Assessment of creatinine clearance, Framingham risk score, carotid intimal medial thickness, and brachial artery flow-mediated dilation.
  • Measurement of highly sensitive C-reactive protein, parathyroid hormone, kidney function tests, and lipid profiles.

Main Results:

  • Decreased creatinine clearance correlated with increased Framingham risk score and carotid intimal medial thickness.
  • Highly sensitive C-reactive protein showed a significant positive correlation with Framingham risk score and an inverse correlation with creatinine clearance.
  • Impaired flow-mediated dilation was associated with higher cardiovascular risk and lower kidney function.

Conclusions:

  • CKD is associated with impaired vascular function, subclinical atherosclerosis, and elevated inflammation.
  • CKD patients face a heightened risk of cardiovascular events due to increased long-term cardiovascular risk.
Abstract

Keywords:
Carotid intimal medial thicknessChronic kidney diseaseFramingham riskInflammation

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