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Development of Venous Thromboembolism After COVID-19 mRNA-1273 Vaccine Inoculation
Abdullahi E Mahgoub1,2, Dominic Awuah1,2, MurtazaShabbir Hussain1,2
1Internal Medicine, Hurley Medical Center, Flint, USA.
Cureus
|March 21, 2022
Summary
A rare case of provoked venous thrombosis, including deep vein thrombosis and pulmonary embolism, occurred in a 79-year-old man after his first mRNA-1273 COVID-19 vaccine dose. This highlights a potential adverse event, though vaccine benefits remain substantial.
Area of Science:
- Immunology
- Cardiovascular Medicine
- Pharmacovigilance
Background:
- The mRNA-1273 (Moderna) COVID-19 vaccine is widely administered for pandemic control.
- Venous thromboembolism (VTE) is a known potential adverse event associated with some vaccines.
- Understanding vaccine-related risks is crucial for ongoing public health strategies.
Observation:
- A 79-year-old male experienced acute right lower extremity pain and swelling post-first mRNA-1273 vaccine dose.
- The patient subsequently received a second vaccine dose despite initial symptoms.
- Diagnostic workup revealed extensive deep venous thrombosis (DVT) and pulmonary embolism (PE).
Findings:
- The patient was diagnosed with provoked venous thrombosis, specifically DVT and PE, temporally associated with mRNA-1273 vaccination.
- Therapeutic anticoagulation was initiated for the VTE.
- The patient was discharged on supplemental oxygen, indicating significant clinical impact.
Implications:
- This case represents one of the initial reports of vaccine-provoked VTE following mRNA-1273 administration during the pharmacovigilance period.
- While rare, this adverse event warrants continued monitoring and investigation into potential mechanisms.
- The established benefits of COVID-19 vaccination in preventing severe disease are considered to outweigh the risks of such rare adverse events.
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