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Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein
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Adipokine Retinol Binding Protein 4 and Cardiovascular Diseases

Yanjing Ji1, Jinyou Song1, Tianhong Su1

  • 1Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Frontiers in Physiology
|March 21, 2022
PubMed

Insights

Cardiovascular diseases (CVDs) are a growing global threat. This review highlights Retinol-Binding Protein 4 (RBP4) as a potential biomarker for predicting CVD risks and related conditions.

Area of Science:

  • Biochemistry
  • Cardiology
  • Endocrinology

Background:

  • Cardiovascular diseases (CVDs) represent a leading global cause of mortality, with increasing incidence in younger populations.
  • Early detection and risk prediction are critical for managing CVDs, necessitating the identification of novel biomarkers.
  • Retinol-binding protein 4 (RBP4), an adipokine, is implicated in insulin resistance and has emerging associations with CVDs and associated risk factors.

Purpose of the Study:

  • To review recent research on the association between Retinol-Binding Protein 4 (RBP4) and cardiovascular diseases (CVDs).
  • To explore the correlation between RBP4 and major CVD risk factors, including hypertension, obesity, and hyperlipidemia.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of studies investigating RBP4 levels in relation to CVDs and risk factors.
  • Synthesis of findings on the role of RBP4 in cardiovascular health.

Main Results:

  • RBP4 is increasingly recognized for its association with various cardiovascular conditions, including hypertension, coronary heart disease, and heart failure.
  • Evidence suggests a link between elevated RBP4 levels and key CVD risk factors such as obesity and hyperlipidemia.
  • RBP4's role in insulin resistance may contribute to its detrimental effects on cardiovascular health.

Conclusions:

  • RBP4 is a promising biomarker for cardiovascular disease risk assessment.
  • Further research into RBP4's mechanisms could lead to novel therapeutic strategies for CVD prevention and treatment.
  • Understanding the RBP4-CVD axis is crucial for addressing the global burden of cardiovascular diseases.

Keywords:
adipokinecardiovascular diseaselipids metabolismretinol-binding protein 4vascular injury

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