Related Experiment Video

Updated: Sep 29, 2025

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
07:22

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

39.0K

The Role of Peroxisome Proliferator-Activated Receptor Gamma and Atherosclerosis: Post-translational Modification and

Liqin Yin1, Lihui Wang2, Zunhan Shi1

  • 1School of Kinesiology, Shanghai University of Sport, Shanghai, China.

Frontiers in Physiology
|March 21, 2022
PubMed

Insights

Peroxisome proliferator-activated receptor gamma (PPARγ) agonists show promise in reducing cardiovascular disease (CVD) risk in type 2 diabetes. Regulating PPARγ activity offers a safer therapeutic target for anti-atherosclerosis treatments.

Area of Science:

  • Molecular biology
  • Endocrinology
  • Cardiovascular research

Background:

  • Atherosclerosis is a major cause of death in type 2 diabetes, with glycemic control offering limited benefit.
  • Thiazolidinediones (TZDs), PPARγ agonists, reduce CVD risk but have adverse effects.
  • PPARγ plays a key role in preventing atherosclerosis by regulating cholesterol efflux and inflammatory cell infiltration.

Purpose of the Study:

  • To review the significance of regulating peroxisome proliferator-activated receptor gamma (PPARγ) activity in atherosclerosis.
  • To explore selective activation and post-translational modification of PPARγ for improved safety.
  • To highlight PPARγ as a safe therapeutic target for anti-atherosclerosis, particularly in diabetic patients.

Main Methods:

  • Literature review focusing on PPARγ's role in atherosclerosis.
  • Analysis of PPARγ agonists, including Thiazolidinediones (TZDs).
  • Examination of PPARγ post-translational modifications and selective activation strategies.

Main Results:

  • PPARγ activation is crucial for anti-atherosclerotic effects, including promoting cholesterol efflux and inhibiting inflammatory cell migration.
  • Selective activation of PPARγ targets may improve the safety profile of PPARγ agonists.
  • Regulation of PPARγ activity is significant in the development and treatment of atherosclerosis.

Conclusions:

  • PPARγ is a critical regulator in preventing atherosclerosis.
  • Targeting PPARγ through selective activation and post-translational modification presents a promising therapeutic strategy.
  • PPARγ represents a valuable and potentially safer target for anti-atherosclerosis therapies in type 2 diabetes.
Keywords:
PPARγatherosclerosiscardiovascular diseasepost-translational modificationsselective modulators

More Related Videos

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

559
LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

13.6K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
54
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.7K
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
14.6K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
141
Protein Import into the Peroxisomes01:27

Protein Import into the Peroxisomes

Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
3.7K
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
6.0K