The intervention on aging system: A classification model, the requirement for five novel categories.

Area of Science:

• Gerontology
• Regenerative Medicine
• Biotechnology

Background:

• Aging is a natural process, but cultural beliefs have limited the pursuit of lifespan extension therapies.
• Emerging longevity therapies show promise in slowing tissue dysfunction and combating aging.
• Recent scientific breakthroughs are rapidly advancing the understanding and treatment of aging.

Purpose of the Study:

• To introduce a novel classification system for individuals based on mortality risk.
• To facilitate targeted interventions for disease resistance and lifespan extension.
• To highlight the burgeoning longevity industry and its potential societal impact.

Main Methods:

• Review of current longevity research, including stem cell therapy, gene therapy, and metabolic interventions.
• Exploration of reprogramming factors (e.g., OSK) and coenzyme replacement (nicotinamide adenine dinucleotide).
• Discussion of scientific approaches such as fasting, fasting mimetics, and blood dilution.

Main Results:

• Numerous scientific disciplines are contributing to the development of anti-aging therapies.
• Therapies are emerging to prevent or reverse key aging drivers.
• A new classification system is proposed to stratify individuals by mortality potential.

Conclusions:

• Longevity science is rapidly evolving, creating a new industry focused on extending healthspan.
• The proposed classification system can guide public health strategies and individual choices.
• Enhancing disease resistance through targeted interventions offers significant benefits for individuals and society.