Related Experiment Video
Updated: Sep 29, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Serum CTRP9 Reflects Coronary Collateralization in Nondiabetic Patients with Obstructive Coronary Artery Disease
Ang Gao1, Jinxing Liu2, Yan Liu1
1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Insights
Serum C1q/tumor necrosis factor-related protein 9 (CTRP9) is higher in patients with well-developed coronary collateral circulation. Higher CTRP9 levels are associated with better collateralization in non-diabetic obstructive coronary artery disease patients.
Area of Science:
- Cardiology
- Biochemistry
- Medical Research
Background:
- Obstructive coronary artery disease (CAD) poses significant health risks.
- Coronary collateral circulation (CCC) plays a crucial role in mitigating ischemic damage.
- Factors influencing CCC development are vital for understanding CAD progression.
Purpose of the Study:
- To investigate the association between serum C1q/tumor necrosis factor-related protein 9 (CTRP9) and the formation of coronary collateral circulation in patients with obstructive CAD.
- To determine if CTRP9 levels can serve as a biomarker for well-developed CCC.
Main Methods:
- 206 obstructive CAD patients underwent coronary angiography.
- Serum CTRP9 levels were measured using ELISA.
- Coronary collateralization was assessed using the Rentrop classification system.
Main Results:
- Serum CTRP9 levels were significantly higher in patients with well-developed CCC.
- Impaired CCC prevalence decreased with increasing CTRP9 tertiles (P for trend <0.001).
- Serum CTRP9 was independently associated with well-developed CCC, particularly in non-diabetic individuals.
Conclusions:
- Serum CTRP9 is a significant indicator of well-developed coronary collateralization in non-diabetic patients with obstructive CAD.
- A serum CTRP9 level ≥ 1.217 suggests a higher likelihood of forming well-developed coronary collaterals.
Aim:
To explore the association between the serum C1q/tumor necrosis factor-related protein 9 (CTRP9) and the formation of coronary collateral circulation in obstructive coronary artery disease (CAD).
Methods:
A total of 206 patients who underwent coronary angiography at Beijing Anzhen Hospital and had epicardial arteries with at least 95% stenotic lesion were enrolled. Blood samples were taken after an overnight fasting before the coronary angiography. Serum CTRP9 level was measured using commercial enzyme linked immunosorbent assay (ELISA) kit. The development of coronary collateralization was determined according to the Rentrop classification system. Rentrop score 0-1 was graded as impaired or less-developed coronary collateralization (n = 54) while the Rentrop score 2-3 was defined as well-developed collateralization (n = 152).
Results:
Serum CTRP9 level was significantly higher in well-developed collateralization and diabetes groups (P < 0.001). To further explore the association between the CTRP9 level and coronary collateralization, the enrolled participants were divided into 3 tertiles according to the serum CTRP9 level. The prevalence of impaired coronary collateralization decreased stepwise with the increasing CTRP9 tertiles (P for trend <0.001). Multivariate regression analysis showed that the serum CTRP9 is independently associated with well-developed collateralization, with an OR (95% CI) of 4.49 (1.75-11.55) and 8.98 (2.75-29.35) in the tertiles 2 and 3, respectively. The following subgroup and receiver-operating characteristic (ROC) analysis also indicated that the diagnostic value of serum CTRP9 level for detecting the formation of collateralization persisted only in nondiabetic participants. Lastly, adding the serum CTRP9 into the baseline model could increase the diagnostic value of established model consisting of relevant factor for the discrimination of well-developed collateralization only in the nondiabetic group (P = 0.046).
Conclusions:
Serum CTRP9 reflects well-developed coronary collateralization in nondiabetic patients with obstructive CAD, and CTRP9 level ≥ 1.217 indicated a greater chance to forming well-developed coronary collaterals.
Related Concept Videos
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:26Coronary Artery Disease II: Pathophysiology
01:30Acute Coronary Syndrome I: Introduction
01:27Coronary Artery Disease V: Interprofessional Care