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Updated: Jul 11, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
Published on: June 7, 2015
Customized Hydrogel for Sustained Release of Highly Water-Soluble Drugs
Xin Jin1, Cheng-Xiong Wei1, Cheng-Wei Wu1
1State Key Laboratory of Structure Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, China.
Abstract:
Highly water-soluble drugs, due to the rapid diffusion in water, are difficult to be released sustainably. To address the issue, a hydrogel with a core-shell structure is designed for the release of highly water-soluble drugs. The core is used to load the drug and the shell is devoted to isolating the drug from the release medium, which can decrease the drug concentration gradient and the driving force of drug release. The core-shell structure prolongs the drug release time by extending the drug release pathway. Moreover, the core-shell hydrogel possesses high swelling properties to reside in the stomach. The results demonstrate that the customized hydrogel can prolong the release of the highly water-soluble drug (metformin hydrochloride) for more than 50 h and alleviate the burst release of the drug.
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