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The Interplay Between Brain Vascular Calcification and Microglia.

Upasana Maheshwari¹, Sheng-Fu Huang¹, Sucheta Sridhar^1,2

¹Department of Neurosurgery, Clinical Neuroscience Center, Zürich University Hospital, University of Zürich, Zurich, Switzerland.

Frontiers in Aging Neuroscience

|March 21, 2022

Summary

This summary is machine-generated.

Brain vascular calcifications, the buildup of calcium and phosphate in brain vessels, are poorly understood. This review explores their occurrence, pathogenesis, and the role of microglia in clearing these calcifications.

Keywords:

astrocyte cerebrovascular calcification ectopic calcification microglia mouse model pericyte primary familial brain calcification vascular aging

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Area of Science:

Neuroscience
Pathology
Radiology

Background:

Vascular calcifications involve ectopic calcium and phosphate deposition in blood vessels.
They are frequently detected via imaging and autopsy, often linked to disease.
Central nervous system vascular calcification is less understood than in peripheral organs.

Purpose of the Study:

To review brain vessel calcifications in aging and neurological diseases.
To discuss the pathomechanisms of brain vascular calcification.
To highlight the role of microglia in brain calcification.

Main Methods:

Literature review of studies on brain vascular calcification.
Discussion of pathomechanisms, focusing on primary familial brain calcification.
Analysis of microglial response and clearance mechanisms.

Main Results:

Brain vascular calcification occurs with aging and in various brain diseases.
Primary familial brain calcification serves as a model for understanding pathogenesis.
Microglia show specific responses to vessel calcification, potentially aiding clearance.

Conclusions:

Brain vascular calcification is an understudied area with implications for aging and disease.
Understanding the pathomechanisms is crucial for therapeutic strategies.
Microglia play a significant role in the brain's response to vascular calcification.