Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Kidney Structure

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Optimizing reporting and outreach for surveillance and risk-reducing surgeries for cancer genetic predisposition: Findings of a workshop organized by the International Cascade Consortium.

Public health genomics·2026

Same author

Cascade Testing Barriers: How to Overcome?

International journal of cancer·2026

Same author

Understanding shared and sex-specific considerations in hereditary breast and ovarian cancer (HBOC) testing decision-making in Singapore.

Journal of genetic counseling·2026

Same author

Deep learning analysis of breast cancer histology predicts ATM pathogenic variant carrier status.

NPJ digital medicine·2026

Same author

Genomic landscape of drug binding and pharmacogenetic variation across diverse populations using SNPdrug3D.

Nature communications·2026

Same author

Updated ENIGMA recommendations for reporting germline variants in cancer susceptibility genes and their translation into twenty languages.

Journal of medical genetics·2026

Same journal

Epigenetic plasticity and chemoresistance in cancer: mechanisms, biomarkers, and translational opportunities for real-world evidence.

Frontiers in cell and developmental biology·2026

Same journal

Matched embryo-endometrium RNA-seq reveals coordinated but asymmetric transcriptomic reprogramming at the onset of early equine pregnancy.

Frontiers in cell and developmental biology·2026

Same journal

Myelin development in the peripheral nervous system of <i>Trachemys scripta</i>.

Frontiers in cell and developmental biology·2026

Same journal

A deep learning-based classification method for subclinical zonular laxity in AS-OCT images.

Frontiers in cell and developmental biology·2026

Same journal

Advancing fat graft survival: from adipose-derived stem cell mechanisms to next-generation regenerative strategies.

Frontiers in cell and developmental biology·2026

Same journal

CRISPR-based next-generation molecular diagnostics for bone infection.

Frontiers in cell and developmental biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 29, 2025

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos

Published on: February 17, 2023

Studying Kidney Diseases Using Organoid Models.

Meng Liu¹, Angelysia Cardilla¹, Joanne Ngeow^1,2

¹Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.

Frontiers in Cell and Developmental Biology

|March 21, 2022

Summary

This summary is machine-generated.

Chronic kidney disease (CKD) is rising globally. Kidney organoids offer a promising new approach for modeling diseases and evaluating drugs, overcoming limitations of traditional methods.

Keywords:

PKD differentiation disease modelling iPSC kidney disease kidney organoid tubuloid tumoroid

More Related Videos

Generation of Human Kidney Tubuloids from Tissue and Urine

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

Author Spotlight: Optimizing iPSC Differentiation for Efficient Production to Generate Kidney Organoids

Author Spotlight: Optimizing iPSC Differentiation for Efficient Production to Generate Kidney Organoids

Published on: September 1, 2023

Related Experiment Videos

Last Updated: Sep 29, 2025

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos

Published on: February 17, 2023

Generation of Human Kidney Tubuloids from Tissue and Urine

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

Author Spotlight: Optimizing iPSC Differentiation for Efficient Production to Generate Kidney Organoids

Author Spotlight: Optimizing iPSC Differentiation for Efficient Production to Generate Kidney Organoids

Published on: September 1, 2023

Area of Science:

Regenerative Medicine
Stem Cell Biology
Nephrology Research

Background:

Chronic kidney disease (CKD) prevalence is increasing globally, driven by diabetes and cardiovascular diseases.
Current therapeutic options like dialysis and transplantation have limitations, highlighting the need for novel treatment strategies.
Traditional research models (animal studies, cell cultures) face challenges in translation and maintaining cellular phenotypes.

Purpose of the Study:

To summarize current kidney organoid models.
To discuss advances in kidney disease modeling using organoids.
To identify challenges and propose solutions for applying organoids in disease modeling and drug evaluation.

Main Methods:

Generation of 3D kidney organoids from various cell sources, including human pluripotent stem cells (hPSCs).
Utilizing gene editing tools with hPSC-derived kidney organoids for modeling genetic kidney diseases.
Reviewing current literature on kidney organoid development and applications.

Main Results:

Successful generation of 3D kidney organoids from hPSCs, adult/fetal renal tissues, and kidney cancer biopsies.
hPSC-derived kidney organoids are being used to model genetic kidney diseases.
Adult kidney-derived tubuloids and kidney cancer-derived tumoroids are emerging models.

Conclusions:

Kidney organoids represent a significant advancement in understanding and modeling kidney diseases.
Further development is needed to overcome challenges in organoid application for disease modeling and drug screening.
Future solutions may enhance the utility of organoids in nephrology research and therapeutics.