Related Experiment Video
Updated: Sep 29, 2025
08:51
Author Spotlight: Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining
Published on: April 21, 2023
3.6K
Hearing Function, Degeneration, and Disease: Spotlight on the Stria Vascularis
Matsya R Thulasiram1, Jacqueline M Ogier2, Alain Dabdoub1,2,3
1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Frontiers in Cell and Developmental Biology
|March 21, 2022
Summary
The stria vascularis (SV) is crucial for hearing. This review explores SV function, degeneration mechanisms, and therapies for hearing loss, offering insights into molecular networks and otoprotective strategies.
Area of Science:
- Oto-science
- Cellular Biology
- Physiology
Background:
- The stria vascularis (SV) is a vital cochlear tissue essential for hearing.
- It maintains cochlear fluid homeostasis and acts as a blood-labyrinth barrier.
- SV degeneration is linked to age-related hearing loss and various auditory disorders.
Purpose of the Study:
- To review recent discoveries on SV molecular regulatory networks.
- To elucidate mechanisms of SV degeneration.
- To discuss otoprotective strategies and clinical developments for SV-related hearing loss.
Main Methods:
- Literature review of recent scientific publications.
- Analysis of molecular mechanisms and cellular functions within the SV.
- Examination of clinical developments and therapeutic strategies.
Main Results:
- Recent discoveries have elucidated molecular networks governing SV function.
- Mechanisms underlying SV degeneration are being uncovered.
- Otoprotective strategies and clinical treatments for SV-related hearing loss are advancing.
Conclusions:
- Understanding SV function and degeneration is critical for treating hearing loss.
- Further research into cell-specific functions and regenerative therapies is needed.
- Otoprotective strategies offer promise for preventing drug-induced hearing damage.
Related Concept Videos
00:50Unrenewable Cells
2.4K
In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
2.4K
01:22Photoreceptors and Visual Pathways
6.6K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.6K
01:15Auditory Pathway
5.9K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
5.9K
01:19The Effect of Aging on Tissues
2.7K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.7K
01:16Anatomy of the Ear
9.1K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
9.1K
01:25Glaucoma: Overview
927
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
927