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Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19
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Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping Review

Wesam Ahmed Nasif1,2, Abeer Shaker El-Moursy Ali3, Mohammed Hasan Mukhtar1

  • 1Biochemistry Department, Faculty of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.

Anemia
|March 21, 2022
PubMed

Insights

Elevated D-dimer levels in COVID-19 patients indicate increased thrombotic activity and are linked to disease severity. D-dimer may serve as a prognostic biomarker for better patient outcomes and reduced mortality.

Area of Science:

  • Biochemistry
  • Hematology
  • Infectious Diseases

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection triggers prothrombotic states.
  • D-dimer, a fibrin degradation product, reflects thrombotic activity.
  • Elevated D-dimer levels are associated with COVID-19 severity.

Purpose of the Study:

  • To review existing literature on the association between D-dimer levels and COVID-19 severity and prognosis.
  • To evaluate the efficacy of anticoagulant therapies in managing COVID-19.

Main Methods:

  • Comprehensive literature search of MEDLINE/PubMed, Scopus, and Web of Science.
  • Keywords included COVID-19, D-Dimer, Thrombosis, Fibrin network, Anticoagulant therapy, Inflammation, and disease severity.
  • Scoping review of retrieved articles and clinical experience.

Main Results:

  • D-dimer is a marker of thrombotic activity, formed from fibrin network degradation.
  • SARS-CoV-2 infection induces prothrombotic changes, correlating positively with D-dimer levels.
  • D-dimer levels are postulated to be associated with COVID-19 disease severity.

Conclusions:

  • D-dimer shows potential as a biomarker for predicting COVID-19 prognosis and outcomes.
  • Utilizing D-dimer for risk stratification can personalize clinical management.
  • Early identification via D-dimer may reduce mortality and accelerate recovery in COVID-19 patients.
Abstract

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