Establishment of Multiple Parameter Reference Intervals for Different Age Groups in Qingdao, China.

Area of Science:

• Clinical Biochemistry
• Human Physiology
• Population Health

Background:

• Establishing accurate reference intervals is essential for interpreting clinical laboratory results.
• Age and sex are known to influence various physiological parameters.
• Previous studies may not reflect the specific demographic characteristics of Qingdao, China.

Purpose of the Study:

• To establish multiple parameter reference intervals for different age and sex groups in Qingdao, China.
• To identify age- and sex-specific variations in key biochemical and hormonal markers.
• To provide a basis for improved disease diagnosis and health evaluation in the local population.

Main Methods:

• Random selection of healthy adult participants from Qingdao, China.
• Categorization into age groups: 18-24, 25-39, 40-49, 50-64, and >65 years.
• Collection of demographic data, questionnaire responses, and serum samples for parameter analysis.

Main Results:

• Significant differences in FBG, AST, BUN, Cr, Hb, FT3, TT3, FT4, TT4, VB12, PROG, CYFRA 21-1, and SCC levels were observed among men of different ages.
• Significant differences in FBG, ALT, AST, BUN, Cr, Hb, TSH, FT3, TT3, FT4, TT4, VB12, CYFRA 21-1, anti-TPO, and ferritin levels were noted among women of different ages.
• Multiple parameters showed significant differences between males and females across various age groups, including FBG, ALT, AST, BUN, Cr, Hb, FT3, TT3, FT4, TSH, VB12, CYFRA 21-1, ferritin, anti-TG, and anti-TPO.

Conclusions:

• Reference intervals for various parameters differ significantly based on age and sex in the Qingdao population.
• The establishment of multiparameter reference intervals is vital for the early diagnosis and evaluation of diseases.
• Implementing these specific reference intervals can reduce misdiagnosis rates and enhance the quality of life for residents in Qingdao.