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Updated: Sep 29, 2025

Characterizing Extracellular Vesicles from Biological Fluids
Published on: February 28, 2025
Bacterial extracellular vesicles as bioactive nanocarriers for drug delivery: Advances and perspectives
Han Liu1, Qin Zhang1, Sicheng Wang1,2
1Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Abstract:
Nanosized extracellular vesicles derived from bacteria contain diverse cargo and transfer intercellular bioactive molecules to cells. Due to their favorable intercellular interactions, cell membrane-derived bacterial extracellular vesicles (BEVs) have great potential to become novel drug delivery platforms. In this review, we summarize the biogenesis mechanism and compositions of various BEVs. In addition, an overview of effective isolation and purification techniques of BEVs is provided. In particular, we focus on the application of BEVs as bioactive nanocarriers for drug delivery. Finally, we summarize the advances and challenges of BEVs after providing a comprehensive discussion in each section. We believe that a deeper understanding of BEVs will open new avenues for their exploitation in drug delivery applications.
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